Effect of Newly Synthesized Methylxanthines on Motility, Fertilization Capacity of Male Gametes and Embryo Quality

Male factor infertility affects 30--40% of the subfertile couples worldwide and that poses a significant medical social issue. Different strategies are developed to increase fertilization potential male gametes during procedures assisted reproduction. One these approaches is addition biologically active molecules, which help stimulate motility spermatozoa. In current investigation, we analysed effect two newly synthesized original methylxanthines (N-61 T-1) on kinetic parameters compared it action pentoxifylline (methylxanthine approved for utilization in clinical practice). It has been found N-61 T-1 biological viability spermatozoa, but do not influence their capacity quality obtained embryos.